Description Module
The Description Module contains narrative descriptions of the clinical trial, including a brief summary and detailed description. These descriptions provide important information about the study's purpose, methodology, and key details in language accessible to both researchers and the general public.
Description Module path is as follows:
Study -> Protocol Section -> Description Module
Description Module
Ignite Creation Date:
2025-12-25 @ 1:46 AM
Ignite Modification Date:
2025-12-25 @ 1:46 AM
NCT ID:
NCT00777894
Brief Summary:
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. This may be an effective treatment for liver cancer.
PURPOSE: This phase I/II trial is studying the side effects and best dose of external-beam radiation therapy in treating patients with liver cancer that cannot be removed by surgery.
Detailed Description:
OBJECTIVES:
* To assess the feasibility and safety of radiotherapy (RT) in patients with hepatocellular carcinoma. (Phase I)
* To assess the safety and efficacy of RT in these patients. (Phase II)
* To generate reproducible peptide patterns of the serum proteome or specific serum sub proteomes in these patients.
* To assess changes in the proteome or sub proteome patterns after RT in these patients.
* To detect peptides that discriminate between before and after RT in these patients.
* To identify these discriminating peptides in these patients.
OUTLINE: This is a multicenter, phase I dose-escalation study followed by a phase II study.
Patients undergo radiotherapy (RT) once daily, five days a week, for 6 weeks. Intensity-modulated, 3-dimensional conformal, or fractionated stereotactic RT may be used.
After completion of study therapy, patients in the phase I portion are followed for 1 year and patients in the phase II portion are followed for 3 years.
Study:
NCT00777894
Study Brief:
Protocol Section:
NCT00777894