Description Module
The Description Module contains narrative descriptions of the clinical trial, including a brief summary and detailed description. These descriptions provide important information about the study's purpose, methodology, and key details in language accessible to both researchers and the general public.
Description Module path is as follows:
Study -> Protocol Section -> Description Module
Description Module
Ignite Creation Date:
2025-12-25 @ 1:33 AM
Ignite Modification Date:
2025-12-25 @ 1:33 AM
NCT ID:
NCT00038194
Brief Summary:
The goal of this clinical research study is to find the highest safe dose of docetaxel in combination with Gleevec (imatinib mesylate) that can be given to men with advanced androgen-independent metastatic prostate cancer that involves bone. Docetaxel is a commercial chemotherapy which interferes with the cancer cell ability to divide and grow.
Detailed Description:
OBJECTIVES:
1. To define the maximum tolerated dose of weekly docetaxel in combination with fixed-dose oral STI571 in adult men with metastatic androgen-independent prostate cancer (AIPC).
2. To determine the qualitative and quantitative toxicity of the combination of oral STI571 and docetaxel.
3. Evaluate PSA modulation with STI571 alone at thirty days in patients with AIPC.
4. Obtain a preliminary estimate of the response rate in AIPC to the combination of STI571 and docetaxel.
5. Obtain tissue for correlative science studies (these are optional studies).
Study:
NCT00038194
Study Brief:
Protocol Section:
NCT00038194