Description Module
The Description Module contains narrative descriptions of the clinical trial, including a brief summary and detailed description. These descriptions provide important information about the study's purpose, methodology, and key details in language accessible to both researchers and the general public.
Description Module path is as follows:
Study -> Protocol Section -> Description Module
Description Module
Ignite Creation Date:
2025-12-25 @ 1:26 AM
Ignite Modification Date:
2025-12-25 @ 1:26 AM
NCT ID:
NCT07165093
Brief Summary:
The aim of the AIS of HEARTS registry is to establish a database to collect, maintain and provide accessible individual patient data from international cohorts and to provide pooled analyses about the yield and value of cardiac computed tomography (CT), acquired during the initial stroke imaging protocol.
The main analysis will investigate the diagnostic yield of cardiac CT to detect cardioembolic sources of stroke in acute ischemic stroke patients.
Detailed Description:
This study is an individual patient data meta-analysis of four different cohorts (4 hospitals) with both prospective and retrospective data. Patients are included if they underwent cardiac CT (ECG gated or non-ECG gated) acquired during the acute stroke scan protocol. The main paper will focus on the diagnostic yield of cardiac thrombi detected on cardiac CT acquired during the acute stroke scan protocol, the comparison with echocardiography and the 90 day follow-up outcomes.
Prospectively planned subanalyses from the AIS of HEARTS registry:
Beyond the analyses focussed on cardiac thrombi, we have prespecified the following analyses:
* Risk stratification of cardioembolic sources in acute ischemic stroke to improve decision making in performing a cardiac CT
* Short term clinical implications of cardiac thrombi detected on cardiac CT
* Long term clinical implications of cardiac thrombi detected on cardiac CT
* Diagnostic yield of ECG-gated versus non-ECG-gated cardiac CT in the acute phase of ischemic stroke
* Association between left atrial appendage contrast filling characteristics and recurrent stroke
* Association between left atrial appendage (LAA) morphology/volume and LAA thrombus
* Cardiac thrombus and associations with medium vessel occlusions strokes
* High-risk cardioembolic sources on cardiac CT in TIA patients
* Clinical relevance of valvular vegetations detected on cardiac CT
* Long term clinical implications of left atrial diverticula detected on cardiac CT
* Incidental findings on cardiac CT We are planning to perform these additional analyses once the main paper has been accepted/submitted.
Study:
NCT07165093
Study Brief:
Protocol Section:
NCT07165093