Bio Spec Overview
Ignite Creation Date:
2025-12-26 @ 12:18 PM
Last Modification Date:
2025-12-26 @ 12:18 PM
Retention:
SAMPLES_WITH_DNA
Description:
In patients included in Part B, approx. 7 ml of arterial or venous blood will be drawn each morning during the study period. Standard EDTA containing vacutainers are used for blood sampling and placed into ice until centrifugation. Blood will be centrifuged at 4 degrees by study nurse or central laboratory of the study site, after which plasma will be separated and stored at -80 degrees in eppendorf vials containing 1 ml of plasma, marked and labelled with study code numbers.
10 ml of urine will be sampled each morning Timing of admission day sample at time of plasma sampling (6 AM) from the collection bag and stored at -80 degrees. 2 eppendorf test-tubes containing 1 ml are used for urine sampling.
Samples for citrulline measurements will be shipped to University of East Anglia, Norwich, United Kingdom and other samples to Maastricht University Medical Center, Netherland, for biochemical analyses to be performed.
10 ml of urine will be sampled each morning Timing of admission day sample at time of plasma sampling (6 AM) from the collection bag and stored at -80 degrees. 2 eppendorf test-tubes containing 1 ml are used for urine sampling.
Samples for citrulline measurements will be shipped to University of East Anglia, Norwich, United Kingdom and other samples to Maastricht University Medical Center, Netherland, for biochemical analyses to be performed.
Section:
In patients included in Part B, approx. 7 ml of arterial or venous blood will be drawn each morning during the study period. Standard EDTA containing vacutainers are used for blood sampling and placed into ice until centrifugation. Blood will be centrifuged at 4 degrees by study nurse or central laboratory of the study site, after which plasma will be separated and stored at -80 degrees in eppendorf vials containing 1 ml of plasma, marked and labelled with study code numbers.
10 ml of urine will be sampled each morning Timing of admission day sample at time of plasma sampling (6 AM) from the collection bag and stored at -80 degrees. 2 eppendorf test-tubes containing 1 ml are used for urine sampling.
Samples for citrulline measurements will be shipped to University of East Anglia, Norwich, United Kingdom and other samples to Maastricht University Medical Center, Netherland, for biochemical analyses to be performed.