Bio Spec Overview
Ignite Creation Date:
2025-12-24 @ 2:49 PM
Last Modification Date:
2025-12-24 @ 2:49 PM
Retention:
SAMPLES_WITH_DNA
Description:
We propose to phenotype CYP2D6 in post-operative patients treated by tramadol by monitoring seric concentrations of O-demethyl tramadol and tramadol to make a ratio in comparision with genotype, and to find a threeshold to determine poor metabolizers. As already described, genotyping CYP2D6 will use a rapid detection method of the alleles implicated in poor metabolizer status (CYP2D6\*3, \*4, \*5 et \*6) in a caucasian population
Section:
We propose to phenotype CYP2D6 in post-operative patients treated by tramadol by monitoring seric concentrations of O-demethyl tramadol and tramadol to make a ratio in comparision with genotype, and to find a threeshold to determine poor metabolizers. As already described, genotyping CYP2D6 will use a rapid detection method of the alleles implicated in poor metabolizer status (CYP2D6\*3, \*4, \*5 et \*6) in a caucasian population