Bio Spec Overview
Ignite Creation Date:
2026-03-26 @ 3:16 PM
Last Modification Date:
2026-03-26 @ 3:16 PM
Retention:
SAMPLES_WITH_DNA
Description:
The study will retain the following biospecimens collected before and after cardiac surgery:
Peripheral blood samples, including whole blood, plasma/serum, and PBMCs for:
Genetic analysis (targeted SNP panels; potential NGS/WGS), Epigenetic profiling (DNA methylation), Transcriptomics (RNA-seq), Proteomic and metabolomic testing, Routine laboratory biomarkers (e.g., creatinine, NGAL, cystatin C, KIM).
Urine samples for short-chain RNA (scRNA) transcriptomic analyses and metabolomic profiling (pre- and postoperative).
Stool samples for microbiota and microbiome studies, including bacterial fractions, extracellular vesicles, and metabolite fractions, analyzed with GC-MS and LC-MS/MS and via metagenomic sequencing.
Digital biospecimens: non-invasive voice and video recordings collected to identify acoustic and image biomarkers of postoperative delirium.
Peripheral blood samples, including whole blood, plasma/serum, and PBMCs for:
Genetic analysis (targeted SNP panels; potential NGS/WGS), Epigenetic profiling (DNA methylation), Transcriptomics (RNA-seq), Proteomic and metabolomic testing, Routine laboratory biomarkers (e.g., creatinine, NGAL, cystatin C, KIM).
Urine samples for short-chain RNA (scRNA) transcriptomic analyses and metabolomic profiling (pre- and postoperative).
Stool samples for microbiota and microbiome studies, including bacterial fractions, extracellular vesicles, and metabolite fractions, analyzed with GC-MS and LC-MS/MS and via metagenomic sequencing.
Digital biospecimens: non-invasive voice and video recordings collected to identify acoustic and image biomarkers of postoperative delirium.
Section:
The study will retain the following biospecimens collected before and after cardiac surgery:
Peripheral blood samples, including whole blood, plasma/serum, and PBMCs for:
Genetic analysis (targeted SNP panels; potential NGS/WGS), Epigenetic profiling (DNA methylation), Transcriptomics (RNA-seq), Proteomic and metabolomic testing, Routine laboratory biomarkers (e.g., creatinine, NGAL, cystatin C, KIM).
Urine samples for short-chain RNA (scRNA) transcriptomic analyses and metabolomic profiling (pre- and postoperative).
Stool samples for microbiota and microbiome studies, including bacterial fractions, extracellular vesicles, and metabolite fractions, analyzed with GC-MS and LC-MS/MS and via metagenomic sequencing.
Digital biospecimens: non-invasive voice and video recordings collected to identify acoustic and image biomarkers of postoperative delirium.