Bio Spec Overview
Ignite Creation Date:
2025-12-25 @ 2:17 AM
Last Modification Date:
2025-12-25 @ 2:17 AM
Retention:
SAMPLES_WITH_DNA
Description:
Venous blood samples for the future determination of exploratory biomarkers prior to administration of the PET-tracer will be collected at screening and at each PET examination.
Biomarkers to be analyzed will include, but are not limited to: Nt-proBNP, Collagen I and III, C-terminal propeptide of procollagen type I (PICP), procollagen type I N-terminal propeptide (PINP), ProC3, procollagen type III amino-terminal propeptide (PIIINP), matrix metalloproteinases (MMPs)(e.g. MMP-1, MMP-2, MMP7…), tissue inhibitors of metalloproteinase (TIMPs) (e.g. TIMP1, TIMP-4…), transforming growth factor-β (TGF-β), connective tissue growth factor (CTGF), galectin-3 (Gal-3), pro-inflammatory mediators (tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-4, and IL-6…), microRNA (miR-1, miR-21…).
Biomarkers to be analyzed will include, but are not limited to: Nt-proBNP, Collagen I and III, C-terminal propeptide of procollagen type I (PICP), procollagen type I N-terminal propeptide (PINP), ProC3, procollagen type III amino-terminal propeptide (PIIINP), matrix metalloproteinases (MMPs)(e.g. MMP-1, MMP-2, MMP7…), tissue inhibitors of metalloproteinase (TIMPs) (e.g. TIMP1, TIMP-4…), transforming growth factor-β (TGF-β), connective tissue growth factor (CTGF), galectin-3 (Gal-3), pro-inflammatory mediators (tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-4, and IL-6…), microRNA (miR-1, miR-21…).
Section:
Venous blood samples for the future determination of exploratory biomarkers prior to administration of the PET-tracer will be collected at screening and at each PET examination.
Biomarkers to be analyzed will include, but are not limited to: Nt-proBNP, Collagen I and III, C-terminal propeptide of procollagen type I (PICP), procollagen type I N-terminal propeptide (PINP), ProC3, procollagen type III amino-terminal propeptide (PIIINP), matrix metalloproteinases (MMPs)(e.g. MMP-1, MMP-2, MMP7…), tissue inhibitors of metalloproteinase (TIMPs) (e.g. TIMP1, TIMP-4…), transforming growth factor-β (TGF-β), connective tissue growth factor (CTGF), galectin-3 (Gal-3), pro-inflammatory mediators (tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-4, and IL-6…), microRNA (miR-1, miR-21…).