Bio Spec Overview
Ignite Creation Date:
2025-12-25 @ 12:43 AM
Last Modification Date:
2025-12-25 @ 12:43 AM
Retention:
SAMPLES_WITH_DNA
Description:
Blood will be collected at baseline prior to the first dose of tacrolimus, and will will consist of 2 tubes of 5 mL blood (one for PK and one pharmacogenetics). Then, serial blood sampling will occur at 0.5, 1, 2, 4, 6, and 10h after the first tacrolimus dose. On Day -2 and Day -1, blood will be collected prior to the morning dose for the 24h and 48h estimates. On Day 0, blood will again be collected at 0.5, 1, 2, 4, 6, and 10. Also, 10 mL of blood on Day +1, Day +8, and Day +15 (30 mL total) for PD biomarker analysis. For haplo-transplant patients, blood sampling will be similar but will occur on Day +5, Day +6, Day +7, and Day +8 once tacrolimus is initiated, and blood for PD biomarkers will occur on Day +9, Day +16, and Day +23.
Section:
Blood will be collected at baseline prior to the first dose of tacrolimus, and will will consist of 2 tubes of 5 mL blood (one for PK and one pharmacogenetics). Then, serial blood sampling will occur at 0.5, 1, 2, 4, 6, and 10h after the first tacrolimus dose. On Day -2 and Day -1, blood will be collected prior to the morning dose for the 24h and 48h estimates. On Day 0, blood will again be collected at 0.5, 1, 2, 4, 6, and 10. Also, 10 mL of blood on Day +1, Day +8, and Day +15 (30 mL total) for PD biomarker analysis. For haplo-transplant patients, blood sampling will be similar but will occur on Day +5, Day +6, Day +7, and Day +8 once tacrolimus is initiated, and blood for PD biomarkers will occur on Day +9, Day +16, and Day +23.