Bio Spec Overview
Ignite Creation Date:
2025-12-24 @ 9:55 PM
Last Modification Date:
2025-12-24 @ 9:55 PM
Retention:
SAMPLES_WITH_DNA
Description:
Study participants were genotyped to 907,763 single nucleotide polymorphisms (SNPs) using the Illumina 1M and 1M-Duo genotyping arrays. Sample quality control inclusion criteria were: (1) concordance between self-reported sex and X-chromosome estimated sex; (2) sample call rate \>95%, (3) concordance between self-reported African ancestry and ancestry estimated using genotyped SNPs, and (4) proportional sharing of genotypes \< 15% between samples, excluding close relatives from the final sample. SNPs in HANDLS were selected when the following criteria were met: (1) Hardy-Weinberg equilibrium p-value (HWE P \>10-7); (2) Missing by haplotype P \> 10-7; (3) Minor allele frequency\>0.01, and (4) SNP call rate \>95%. Quality control and data management for each genotype was conducted using PLINKv1.06.
Section:
Study participants were genotyped to 907,763 single nucleotide polymorphisms (SNPs) using the Illumina 1M and 1M-Duo genotyping arrays. Sample quality control inclusion criteria were: (1) concordance between self-reported sex and X-chromosome estimated sex; (2) sample call rate \>95%, (3) concordance between self-reported African ancestry and ancestry estimated using genotyped SNPs, and (4) proportional sharing of genotypes \< 15% between samples, excluding close relatives from the final sample. SNPs in HANDLS were selected when the following criteria were met: (1) Hardy-Weinberg equilibrium p-value (HWE P \>10-7); (2) Missing by haplotype P \> 10-7; (3) Minor allele frequency\>0.01, and (4) SNP call rate \>95%. Quality control and data management for each genotype was conducted using PLINKv1.06.