Bio Spec Overview
Ignite Creation Date:
2025-12-24 @ 1:10 PM
Last Modification Date:
2025-12-24 @ 1:10 PM
Retention:
SAMPLES_WITH_DNA
Description:
The aim of this study is to identify why a subset of COPD patients develops such a severe COPD at early age and with relatively few packyears smoking. This will need a functional genomics approach integrating both whole genome DNA sequencing data in blood and transcriptomics data in the bronchial epithelium as well as epigenetic regulation. This will identify novel common and rare genetic variants, genes, miR's, and DNA methylation sites that contribute to severe early-onset COPD.
Section:
The aim of this study is to identify why a subset of COPD patients develops such a severe COPD at early age and with relatively few packyears smoking. This will need a functional genomics approach integrating both whole genome DNA sequencing data in blood and transcriptomics data in the bronchial epithelium as well as epigenetic regulation. This will identify novel common and rare genetic variants, genes, miR's, and DNA methylation sites that contribute to severe early-onset COPD.