Ignite Creation Date:
2025-12-25 @ 12:53 AM
Ignite Modification Date:
2026-03-11 @ 5:02 PM
Study NCT ID:
NCT04896567
Status:
WITHDRAWN
Last Update Posted:
2022-08-03
First Post:
2018-08-31
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Isolation of Cells From Biopsy Tissue to Aid in Kidney Repair
Sponsor:
Brigham and Women's Hospital
Organization:
Study Overview
Official Title:
Isolation of Cells From Biopsy Tissue to Aid in Kidney Repair
Status:
WITHDRAWN
Status Verified Date:
2022-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Superseded by a separate study
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Endothelial progenitor cells that reside in renal vasculature may be stimulated to initiate differentiation programs during episodes of injury. It is hypothesized that endothelial progenitor cells resident in the kidney can transition to a post-injury phenotype that promotes endothelial repair.
Detailed Description:
Endothelial dysfunction is central to the pathophysiology of vascular ischemia, bacterial sepsis, toxin-induced thrombotic microangiopathy, and antibody-mediated kidney transplant rejection and often manifest with renal failure. With each of these diagnoses circulating components of the complement cascade bind to endothelial cells and induce disease progression through anaphylactic cellular messaging, monocyte homing, and direct cell membrane disruption. In response to injury during embryologic development avascular metanephric blastema initiate endothelial differentiation. Although circulating hematopoietic progenitor cells have shown therapeutic promise they incorporate into renal vasculature at very low density.
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: