Ignite Creation Date:
2025-12-24 @ 1:55 PM
Ignite Modification Date:
2026-02-20 @ 11:25 AM
Study NCT ID:
NCT02405195
Status:
COMPLETED
Last Update Posted:
2019-05-07
First Post:
2015-03-27
Is Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Renal Perfusion, Filtration and Oxygenation During Cardiopulmonary Bypass (CPB)
Sponsor:
Sahlgrenska University Hospital
Organization:
Study Overview
Official Title:
Renal Perfusion, Filtration and Oxygenation During Cardiopulmonary Bypass (CPB)
Status:
COMPLETED
Status Verified Date:
2019-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ECCSTUD
Brief Summary:
Acute kidney injury is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). This study aims to investigate the effects of CPB on renal perfusion, filtration and oxygenation.
Detailed Description:
After approval of the regional ethics committee, patients (n=16) undergoing combined cardiac surgery procedures during normothermic CPB will be included after informed consent. Systemic and renal variables will be measured by pulmonary artery and renal vein catheters. Glomerular filtration rate (GFR) will be measured by renal extraction of 51Cr-EDTA and renal blood flow (RBF) by the infusion clearance technique for para-aminohippuric acid (PAH) corrected for by renal extraction of PAH. Repeated measures ANOVA followed by Fisher's PLSD post-hoc test were used for statistical analyses
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: