Ignite Creation Date:
2025-12-24 @ 10:15 PM
Ignite Modification Date:
2026-03-13 @ 4:38 PM
Study NCT ID:
NCT05648435
Status:
COMPLETED
Last Update Posted:
2023-04-12
First Post:
2022-12-05
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Lithium Clearance in Patients With High Risk of Acute Kidney Injury
Sponsor:
University Hospital of North Norway
Organization:
Study Overview
Official Title:
Proximal Tubule Function in Septic Patients as Measured by Endogenous Lithium Clearance
Status:
COMPLETED
Status Verified Date:
2022-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Renal lithium clearance is hypothesized to be a useful indicator of renal tubular function.
In this study lithium clearance will be monitored in patients with sepsis associated acute kidney injury and in healthy controls.
In this study lithium clearance will be monitored in patients with sepsis associated acute kidney injury and in healthy controls.
Detailed Description:
Lithium is almost completely reabsorbed in the proximal tubule in parallel with sodium and water. What is not reabsorbed here is assumed to be fully excreted in urine, giving a reasonably accurate measurement of sodium reabsorption in the proximal tubule. Endogenous lithium clearance will be measured by inductively coupled plasma mass spectrometry (ICP-MS). The Gomez equations will be applied to calculate efferent arteriolar resistance, afferent arteriolar resistance, glomerular hydrostatic pressure, glomerular filtration pressure, and glomerular oncotic pressure. N-acetyl-β-D glucosaminidase (NAG) and NGAL, markers of tubular injury, will be measured by a spectrophotometric method using a commercially available kit. Routine blood and urine analyses will be performed at the Diagnostic Clinic Laboratory, University Hospital of North Norway, Tromsø.
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: