Ignite Creation Date:
2025-12-25 @ 4:53 AM
Ignite Modification Date:
2026-03-14 @ 5:47 AM
Study NCT ID:
NCT07161518
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2025-09-08
First Post:
2025-08-14
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Characterizing Transcranial Focused Ultrasound Neuromodulation During Sedation
Sponsor:
Stanford University
Organization:
Study Overview
Official Title:
Characterizing Transcranial Focused Ultrasound Neuromodulation During Sedation
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2025-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this clinical trial is to learn if focused ultrasound delivered to the brain influences the effects of the anesthetic medication propofol. It will also learn about the safety and feasibility of using ultrasound and anesthesia together to influence the brain. The main questions it aims to answer are:
* Does focused ultrasound delivered to the brain influence the effects or the strength of propofol?
* Does propofol anesthesia influence the effects of ultrasound delivered to the brain?
Researchers will compare focused ultrasound with sham ultrasound (similar technology but not targeted to a brain region) and administer propofol anesthesia, while measuring signals from the brain and behaviors of participants.
Participants will:
* Obtain one non-contrast MRI scan of the brain
* Receive two separate sessions of ultrasound to the brain (one focused and one sham)
* Undergo two separate sessions of propofol anesthesia in a laboratory
* Does focused ultrasound delivered to the brain influence the effects or the strength of propofol?
* Does propofol anesthesia influence the effects of ultrasound delivered to the brain?
Researchers will compare focused ultrasound with sham ultrasound (similar technology but not targeted to a brain region) and administer propofol anesthesia, while measuring signals from the brain and behaviors of participants.
Participants will:
* Obtain one non-contrast MRI scan of the brain
* Receive two separate sessions of ultrasound to the brain (one focused and one sham)
* Undergo two separate sessions of propofol anesthesia in a laboratory
Detailed Description:
None
Study Oversight
Has Oversight DMC:
True
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: