Ignite Creation Date:
2025-12-25 @ 12:32 AM
Ignite Modification Date:
2026-02-25 @ 5:42 PM
Study NCT ID:
NCT03154567
Status:
COMPLETED
Last Update Posted:
2024-04-23
First Post:
2017-04-25
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Effects of Stress and Drug-cue Exposure (SCM)
Sponsor:
Wayne State University
Organization:
Study Overview
Official Title:
Effects of Stress and Drug-cue Exposure on Craving and Marijuana Seeking Behavior in Regular Cannabis Smokers
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of the proposed study to examine the links among stress, craving for marijuana, and marijuana reminders, or "cues".
In this study, an agent called yohimbine will be used to produce stress-like responses. Yohimbine is known to cause stress response in studies of alcohol and other substance use disorders. This study intends to show it can be used to cause stress in marijuana users as well.
In this study, an agent called yohimbine will be used to produce stress-like responses. Yohimbine is known to cause stress response in studies of alcohol and other substance use disorders. This study intends to show it can be used to cause stress in marijuana users as well.
Detailed Description:
Part of this study will be conducted on a residential unit where participants will live for 7 nights over a 2-week period (4 consecutive nights the 1st week and 3 consecutive nights the 2nd week).
During that time, participants can't leave the unit unescorted or have visitors.
During the inpatient stay participants will participant in experimental sessions where they will be asked to smoke cigarettes containing either marijuana or placebo (a blank).
Participants will be asked to take capsules that could contain yohimbine or placebo (blank).
Participants will be asked to complete questionnaires and will have their vital signs (blood pressure, heart rate) monitored throughout each session.
Participants will be asked to participate in overnight sleep recordings, a polysomnogram (PSG).
During that time, participants can't leave the unit unescorted or have visitors.
During the inpatient stay participants will participant in experimental sessions where they will be asked to smoke cigarettes containing either marijuana or placebo (a blank).
Participants will be asked to take capsules that could contain yohimbine or placebo (blank).
Participants will be asked to complete questionnaires and will have their vital signs (blood pressure, heart rate) monitored throughout each session.
Participants will be asked to participate in overnight sleep recordings, a polysomnogram (PSG).
Study Oversight
Has Oversight DMC:
True
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?: