Ignite Creation Date:
2025-12-25 @ 12:01 AM
Ignite Modification Date:
2026-01-03 @ 7:59 PM
Study NCT ID:
NCT07041658
Status:
NOT_YET_RECRUITING
Last Update Posted:
2025-06-27
First Post:
2025-05-23
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Nutritional Status of Critically Ill Children in Pediatric Intensive Care Units at Sohag University Hospitals
Sponsor:
Sohag University
Organization:
Study Overview
Official Title:
Assessment of Nutritional Status of Critically Ill Children Admitted to Pediatric Intensive Care Units at Sohag University Hospitals
Status:
NOT_YET_RECRUITING
Status Verified Date:
2025-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this observational study is to evaluate nutritional status of critically ill patients admitted to Pediatric Intensive Care Units (PICU) at Sohag University Hospital and its correlation with their outcome as regarding to need for mechanical ventilation, acquired infection, metabolic complications, and mortality.
Detailed Description:
Nutrition is one of the important factors which affect morbidity and mortality in critically ill patients in pediatric intensive care units (PICU). Adequate and balanced nutrition is required not only to support physical growth and basic metabolic needs, but also to ensure proper organ function and sustain daily activities.
Nutritional status reflects the dynamic balance between nutrient availability, dietary intake, and the body's ability to absorb and utilize those nutrients in relation to an individual's specific needs.
Critical illness triggers significant metabolic and endocrine changes which are characterized by catabolism, insulin resistance, stress hyperglycemia and shifts in substrate utilization. These changes closely interact with disruptions in the autonomic and immune systems. Critically ill infants and children may have an increased metabolic need, which predisposes them to nutritional deterioration and malnutrition during illness.
The World Health Organization (WHO) defines malnutrition as " an acute or chronic nutritional status due to deficiency or excess energy, protein and micronutrient resulting in imbalance between nutrient intake and requirement that can negatively affect growth and development".
Malnutrition in critically ill patients is associated with decreased respiratory function, higher rate of nosocomial infections, secondary immunodeficiency, prolonged mechanical ventilation and prolonged hospitalization. It is also related to delayed wound healing process, impairment in gastrointestinal functions, thus increased morbidity and mortality.
The American and European Society of Parenteral and Enteral Nutrition guidelines recommend that nutritional status should be evaluated on admission to the PICU to identify children at risk and to provide nutrition support in the PICU.
Enteral feeding approach has been preferred to be started within the first 24-48 hours after admission to the PICU, if there are no contraindications for enteral nutrition. Early initiation of enteral feeding have been associated with improved clinical outcomes as regard morbidity and mortality. Metabolic demands must be determined by calculating energy consumption.
Malnutrition at PICU admission is frequent (15-25% prevalence rates) in developing countries. A study published in 2022 on the nutritional status of critically ill children in one Egyptian PICU found that malnutrition rate can be around 30%. However, the data on nutritional status in Egyptian PICUs is scarce especially in Upper Egypt. Therefore, assessment of nutritional status in our PICU can help in improving the outcome of critically ill children in terms of both morbidity and mortality.
Nutritional status reflects the dynamic balance between nutrient availability, dietary intake, and the body's ability to absorb and utilize those nutrients in relation to an individual's specific needs.
Critical illness triggers significant metabolic and endocrine changes which are characterized by catabolism, insulin resistance, stress hyperglycemia and shifts in substrate utilization. These changes closely interact with disruptions in the autonomic and immune systems. Critically ill infants and children may have an increased metabolic need, which predisposes them to nutritional deterioration and malnutrition during illness.
The World Health Organization (WHO) defines malnutrition as " an acute or chronic nutritional status due to deficiency or excess energy, protein and micronutrient resulting in imbalance between nutrient intake and requirement that can negatively affect growth and development".
Malnutrition in critically ill patients is associated with decreased respiratory function, higher rate of nosocomial infections, secondary immunodeficiency, prolonged mechanical ventilation and prolonged hospitalization. It is also related to delayed wound healing process, impairment in gastrointestinal functions, thus increased morbidity and mortality.
The American and European Society of Parenteral and Enteral Nutrition guidelines recommend that nutritional status should be evaluated on admission to the PICU to identify children at risk and to provide nutrition support in the PICU.
Enteral feeding approach has been preferred to be started within the first 24-48 hours after admission to the PICU, if there are no contraindications for enteral nutrition. Early initiation of enteral feeding have been associated with improved clinical outcomes as regard morbidity and mortality. Metabolic demands must be determined by calculating energy consumption.
Malnutrition at PICU admission is frequent (15-25% prevalence rates) in developing countries. A study published in 2022 on the nutritional status of critically ill children in one Egyptian PICU found that malnutrition rate can be around 30%. However, the data on nutritional status in Egyptian PICUs is scarce especially in Upper Egypt. Therefore, assessment of nutritional status in our PICU can help in improving the outcome of critically ill children in terms of both morbidity and mortality.
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?: