Ignite Creation Date:
2025-12-25 @ 4:04 AM
Ignite Modification Date:
2026-03-03 @ 10:02 PM
Study NCT ID:
NCT00837902
Status:
COMPLETED
Last Update Posted:
2018-11-30
First Post:
2009-02-04
Is NOT Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Genetic Determinants of Response to Beta Blockade
Sponsor:
Vanderbilt University
Organization:
Study Overview
Official Title:
Genetic Determinants of Response to Beta Blockade
Status:
COMPLETED
Status Verified Date:
2018-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The overall goal of this project is to determine the genetic factors contributing to interindividual differences in response to beta-blockade.
Detailed Description:
The Aim is to define the contribution of genetic variation to the interindividual variability in response to β-blockade. The rationale for the study is as follows: Beta-blockers prevent the activation of β-ARs and thus form the cornerstone of treatment of pathological states such as congestive heart failure and coronary artery disease. Functional polymorphisms in cardiac beta-receptors have been shown to determine response to β-blocker therapy. A physiologic stimulus such as exercise causes sympathetic stimulation and activation of the cardiac β-ARs and genotypic differences in response to β-blockers are magnified under states of heightened sympathetic activity. Thus, in addition to measuring the response to β-blockers at rest, we will also determine the response to β-blockade after sub-maximal exercise on a supine bicycle ergometer. Genetic variations that may alter sensitivity to a beta blocker will be sought.
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
Secondary ID Infos
| Secondary ID | Type | Domain | Link | View |
|---|---|---|---|---|
| P01HL056693 | NIH | None | https://reporter.nih.gov/quic… | View |
| U01HL065962 | NIH | None | https://reporter.nih.gov/quic… | View |
| 1UL1RR024975 | NIH | None | https://reporter.nih.gov/quic… | View |