Ignite Creation Date:
2025-12-25 @ 3:44 AM
Ignite Modification Date:
2026-02-27 @ 4:05 PM
Study NCT ID:
NCT00587002
Status:
COMPLETED
Last Update Posted:
2011-04-15
First Post:
2007-12-21
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Differences in Epicardial Plaque and Microvascular Function in Women With an Acute Myocardial Infarction
Sponsor:
Mayo Clinic
Organization:
Study Overview
Official Title:
Differences in Epicardial Plaque and Microvascular Function in Women With an Acute Myocardial Infarction
Status:
COMPLETED
Status Verified Date:
2011-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The broad objective is to advance our understanding of both in vivo anatomical and functional changes that are present in the coronary arteries in women who have an acute coronary syndrome. Specific focus will be placed on the age of the women as there may be distinct differences in younger women (\< 50 years) given the marked increase in mortality in this population.
Detailed Description:
The hypothesis of the current study is that plaque erosion and microvascular dysfunction are key features responsible for the increased peri-MI mortality in young women. In order to test this hypothesis the following specific aims are proposed using a special intravascular ultrasound technique called virtual histology and microvascular function (effect of intracoronary adenosine on coronary blood flow) in patients coming to the cardiac catheterization laboratory with an acute MI:
1. To determine if plaque rupture or plaque erosion is more prevalent in young women (\<50 years) compared with older women (≥ 50 years) and men in the development of an acute MI
2. To determine if inflammatory mediators of plaque rupture are higher in older women and men with an acute MI compared with younger women
3. To determine if microvascular function is abnormal in young women undergoing percutaneous coronary revascularization with an acute MI compared to older women and men
4. To determine if alterations exist in the number and function of EPCs in young women (\<50 years) compared with older women (≥ 50 years) and men who have had an acute MI and to determine the association with microvascular function
1. To determine if plaque rupture or plaque erosion is more prevalent in young women (\<50 years) compared with older women (≥ 50 years) and men in the development of an acute MI
2. To determine if inflammatory mediators of plaque rupture are higher in older women and men with an acute MI compared with younger women
3. To determine if microvascular function is abnormal in young women undergoing percutaneous coronary revascularization with an acute MI compared to older women and men
4. To determine if alterations exist in the number and function of EPCs in young women (\<50 years) compared with older women (≥ 50 years) and men who have had an acute MI and to determine the association with microvascular function
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
Secondary ID Infos
| Secondary ID | Type | Domain | Link | View |
|---|---|---|---|---|
| Epi-Plaque | None | None | View |